Chemistry & Chemical Biology
CHEM 5630: Nucleic Acid Chemistry
Lecture - 3 credits
- Offers a broadband introduction to the field of nucleic acid chemistry.
- Nucleic acids are vital for biology, but their roles have been greatly expanded beyond storage of genetic information.
- The breadth of utility of nucleic acids stems from a precise understanding of their structures, modern means to synthesize and modify them, and the ability for nucleic acids to engage with varieties of enzymes/proteins and other synthetic/biological systems.
- Foundational topics include nucleic acid structure, physicochemical properties, syntheses of nucleosides/nucleotides/oligonucleotides, chemical modification of nucleic acids, methods to manipulate and analyze nucleic acids (e.g., PCR, sequencing, and electrophoresis).
- Advanced topics include nucleic acid therapeutics (e.g., siRNA, antisense technology, CRISPR, and aptamers); DNA damage and repair; and DNA for materials science (e.g., DNA nanotechnology).
Offers a broadband introduction to the field of nucleic acid chemistry. Show more.